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ADVERSE REACTIONS and CLINICAL STUDIES).

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When fluconazole is used concomitantly with these or other sulfonylurea oral hypoglycemic agents, blood glucose concentrations should be carefully monitored and the dose of the sulfonylurea should be adjusted as necessary (see CLINICAL PHARMACOLOGY, Drug Interaction Studies).

The penicillin-binding protein, to which a particular β-lactam antibiotic binds, affects the morphologic response of the bacterium to the agent.

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Patients who were unable to tolerate the oral study drug could receive intravenous prophylaxis at the same dose for 3 days or less per chemotherapy cycle.

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Fluconazole increases the AUC of saquinavir by approximately 50%, C max by approximately 55%, and decreases clearance of saquinavir by approximately 50% due to inhibition of saquinavir's hepatic metabolism by CYP3A4 and inhibition of P-glycoprotein.

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Prevention of invasive aspergillosis in high-risk patients: Universal versus preemptive, targeted treatment.

Discrepancy between the chemical-genetic and genetic profiles of compounds and their targets could be a result of incomplete inactivation of the target protein function by the drugs or may reflect the inherent differences in genetic versus chemical mechanisms of target inhibition; unlike a gene deletion that eliminates the target protein from the cell, chemical inhibitors form a complex with the target proteins and the inactive complex remains physically present.

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